THE OLD AND THE NEW PLANKTON: ECOLOGICAL REPLACEMENT OF ASSOCIATIONS OF MOLLUSC PLANKTON AND GIANT FILTER FEEDERS AFTER THE CRETACEOUS?

The old and the new plankton: ecological replacement of associations of mollusc plankton and giant filter feeders after the Cretaceous?

Owing to their great diversity and abundance, ammonites and belemnites represented key elements in Mesozoic food webs.Because of their extreme ontogenetic size increase by up to three orders of magnitude, their position in the food webs likely changed during ontogeny.Here, we reconstruct the number of eggs laid by large adult females of these cepha

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Phase II trial of AKT inhibitor MK-2206 in patients with advanced breast cancer who have tumors with PIK3CA or AKT mutations, and/or PTEN loss/PTEN mutation

Abstract Background The PI3K/AKT pathway is activated through PIK3CA or AKT1 mutations and PTEN loss in breast cancer.We conducted a phase II trial with an allosteric AKT inhibitor MK-2206 in patients with advanced breast cancer who had tumors with PIK3CA/AKT1 mutations and/or PTEN loss/mutation.Methods The primary endpoint was objective response r

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